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Home > Chromatin/Epigenetic > Sirt/Sirtuin > Splitomicin
Splitomicin  
Catalog No. T6678    CAS 5690-03-9
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10mg
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80.00
25mg
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175.00
50mg
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280.00
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5g
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10mM * 1mL (in DMSO)
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24.00
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Documents and Quality Management
Purity:99.11% COA Datasheet HNMR HPLC
Biological Activity:

Product Description:

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.

Target:
Sir2p;
Research Area:
Cancer
Chemical Information:
Molecular Weight 198.22
Formula C13H10O2
CAS Number 5690-03-9
Solubility DMSO: 39mg/ml(196.75 mM);Water: <1mg/ml;Ethanol: 39mg/ml(196.75 mM)
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Related Compound Libraries
This product is contained In the following compound libraries:
  • The compound is not included in our libraries at this moment.
Product Recommendations
  • SirReal2, SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
  • Sirtinol, Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
  • SRT2104 (GSK2245840), SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
  • AGK2, AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
  • Fisetin, Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.

 

Reference

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