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Inhibitors & Agonists

product7/SB-505124.html

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Inhibitors & Agonists
2

SB-505124

T2462694433-59-5

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.

ALK TGF-beta/Smad

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SB-505124 hydrochloride

T21637356559-13-2

SB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-β type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces Th17 differentiation in mice by decreasing Il17a and Rorc gene expression and IL-17 protein production.SB-505124 hydrochloride is used in the study of colorectal cancer.

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