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MEK
Cat.No. Product Name Information Area
T3623 Cobimetinib Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK)...
T6843 GDC-0623 GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1... Others
T6785 BI-847325 BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 valu... Others
T6760 APS-2-79 APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antago... Others
T6692 TAK-733 MEK Inhibitor TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and ... Cancer
T6636 Refametinib (RDEA119, Bay 86-9766)hot Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific ... Cancer
T6223 U0126-EtOH U0126-EtOH, a non-ATP competitive specific inhibitor of MEK1/2, with the IC50 for MEK... Cancer
T6218 Selumetinib (AZD6244)hot Selumetinib (AZD6244), an effective, greatly specific MEK1 and ERK1/2 phosphorylatio... Cancer
T6189 PD0325901hot PD0325901(IC50=0.33 nM) is a specific and non-ATP-competitive MEK inhibitor, probably... Cancer
T6152 PD318088 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously... Cancer
T6131 Pimasertib (AS-703026) Pimasertib is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/... Cancer
T6083 AZD8330 AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 n... Cancer
T3001 Honokiol Honokiol is the active principle of magnolia extract. It inhibits the activation of A... Immunology
T2708 SL327 SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to trans... Cancer
T2623 PD98059 PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2 μM) in a cell-free assay; no... Cancer
T2610 BMS-599626 BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and ... Cancer
T2508 Binimetinib (MEK162, ARRY-162, ARRY-438162) Binimetinib (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/... Cancer
T2443 CI-1040 PD184352 (CI-1040, an ATP non-competitive MEK1/2 inhibitor (IC50=17 nM), has been use... Other
T2416 BIX02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. Other
T2327 Pelitinib Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM). Cancer
T2125 Trametinib (GSK1120212)hot Trametinib is a dual-kinase inhibitor that is used in the treatment of advanced malig... Cancer
T6324 BIX 02188 BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic ac... Cancer
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