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Home > Hedgehog-Smoothened
Cat.No. Product Name Information Area
T3588 JK184 JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cel... Others
T3156 Ciliobrevin A Ciliobrevin A is a?hedgehog?(Hh) signaling pathway inhibitor with median inhibitory c... Others
T6891 MK-4101 MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity throug... Others
T3363 Jervinenew Jervine's biological activity is mediated via its interaction with the 7 pass trans m... Others
T6514 Glasdegib (PF-04449913) Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibit... Cancer
T3070 GANT 61 GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedge... Cancer
T2666 LY2940680 Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits He... Cancer
T2590 Vismodegib Vismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog path... Cancer
T2450 SANT-1 SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo... Other
T2299 BMS-833923 BMS-833923 is an orally bioavailable Smoothened antagonist. Phase 2. Cancer
T1926 LDE225 LDE225 (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgeho... Other
T1810 Purmorphamine Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopami... Other
T1779 Smoothened Agonist (SAG) SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates th... Other