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α-Glucosidase-IN-23

🥰Excellent
Catalog No. T67728Cas No. 161187-57-1

α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).

α-Glucosidase-IN-23

α-Glucosidase-IN-23

🥰Excellent
Purity: 98.93%
Catalog No. T67728Cas No. 161187-57-1
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
Pack SizePriceAvailabilityQuantity
1 mg$118In Stock
5 mg$287In Stock
10 mg$392In Stock
25 mg$593In Stock
50 mg$798In Stock
100 mg$1,050In Stock
200 mg$1,390In Stock
1 mL x 10 mM (in DMSO)$343In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.93%
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COA HNMR LCMS LCMS

Product Introduction

Bioactivity
Description
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
In vitro
α-Glucosidase-IN-23 (1 μM) exhibits significant anti-diabetes activity. α-Glucosidase-IN-23 decreases ROS levles in βcells and muscle cells. α-Glucosidase-IN-23 decreases blood glucose by α-glucosidase inhibition (IC50= 4.48 μM)[1].
In vivo
α- Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits α- Glucosidase in mice[1].
Chemical Properties
Molecular Weight373.4
FormulaC20H23NO6
Cas No.161187-57-1
SmilesC(OCC)(=O)C=1C(C(C(OCC)=O)=C(C)NC1C)C2=C3C(=CC=C2)OCO3
Relative Density.1.225 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (66.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6781 mL13.3905 mL26.7809 mL133.9047 mL
5 mM0.5356 mL2.6781 mL5.3562 mL26.7809 mL
10 mM0.2678 mL1.3390 mL2.6781 mL13.3905 mL
20 mM0.1339 mL0.6695 mL1.3390 mL6.6952 mL
50 mM0.0536 mL0.2678 mL0.5356 mL2.6781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α-Glucosidase-IN-23αGlucosidaseIN23α-glucosidasealpha-Glucosidase-IN-23a-Glucosidase-IN-23
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