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TDRL-551

Name: TDRL-551
Brand: TargetMol
SKU: T28935
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28935Cas No. 1644626-43-6

TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction and enhances the efficacy of platinum-based chemotherapy for lung and ovarian cancer.

TDRL-551

🥰Excellent

Purity: 98.09%

Catalog No. T28935Cas No. 1644626-43-6

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$213	In Stock
10 mg	$313	In Stock
25 mg	$663	In Stock
50 mg	$1,060	In Stock
100 mg	$1,730	In Stock
200 mg	$2,330	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock

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Batch Information

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Purity:98.09%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	591.83
Formula	C₂₅H₂₃ClIN₃O₄
Cas No.	1644626-43-6
Smiles	CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1
Relative Density.	1.62 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (101.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6897 mL	8.4484 mL	16.8967 mL	84.4837 mL
5 mM	0.3379 mL	1.6897 mL	3.3793 mL	16.8967 mL
10 mM	0.1690 mL	0.8448 mL	1.6897 mL	8.4484 mL
20 mM	0.0845 mL	0.4224 mL	0.8448 mL	4.2242 mL
50 mM	0.0338 mL	0.1690 mL	0.3379 mL	1.6897 mL
100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.8448 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc