Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.

DPPH&MDA:85.60 μg/mL

In the DPPH and MDA systems, spathulenol demonstrates high antioxidant activity. It shows significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].

Spathulenol, when administered orally at a dose of 300 mg/kg, demonstrates significant inhibition in the mice paw edema and pleurisy model induced by Cg[1].
In a spontaneous lipoperoxidation model using rat brain homogenate, when incubated under controlled temperature and oxygenation conditions, PG-1 exhibits high activity with an IC50 value of 26.13 μg/mL. This activity is comparable to that of the commercial antioxidant BHT (38.41 μg/mL). Consequently, PG-1 contributes to a reduction in the generation of malondialdehyde (MDA), a toxic product resulting from the degradation of cell membranes through lipid peroxidation. This reduction in MDA levels helps prevent cell ruptures and mutations[1].