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Sifalimumab
(Synonyms: MEDI-545, MDX-1103) Copy Product Info
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Synonyms: MEDI-545, MDX-1103
Catalog No. T76760 Copy Product Info
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Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.
Cas No. 1006877-41-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $297 | In Stock | In Stock | |
| 5 mg | $778 | In Stock | In Stock | |
| 10 mg | $1,230 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE. |
| In vitro | Attenuating lymphocyte cytotoxicity co-cultured with U-87MG, sifalimumab is effective at concentrations ranging from 3 to 36 μg/well when applied for 72 hours[1]. |
| In vivo | Treatment with sifalimumab at doses of 30 mg/kg (subcutaneous injection) and 3 μg/g demonstrates a therapeutic effect and attenuates lymphocyte infiltration[1]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | MEDI-545, MDX-1103 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IFNa1 Protein (Fc) at 2 μg/mL (30 μL/well) can bind Sifalimumab. The EC50 is 44.14 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IFNa1 |
| Molecular Weight | 144.24 kDa |
| Cas No. | 1006877-41-3 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Sifalimumab chemical structure | Sifalimumab in vivo | Sifalimumab in vitro | Sifalimumab molecular weight
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