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Pumafentrine

Name: Pumafentrine
Brand: TargetMol
SKU: T71691
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T71691Cas No. 207993-12-2

Alias BY 343

Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.

Pumafentrine

🥰Excellent

Catalog No. T71691Alias BY 343Cas No. 207993-12-2

Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$465	In Stock	In Stock
10 mg	$679	-	In Stock
25 mg	$1,070	-	In Stock
50 mg	$1,430	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:>99.99%

ee:99.77%

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.
Synonyms	BY 343

Chemical Properties

Molecular Weight	477.64
Formula	C₂₉H₃₉N₃O₃
Cas No.	207993-12-2
Smiles	O(C)C=1C=C2C([C@]3([C@@](N=C2C4=CC=C(C(N(C(C)C)C(C)C)=O)C=C4)(CCN(C)C3)[H])[H])=CC1OCC
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0936 mL	10.4681 mL	20.9363 mL	104.6813 mL
5 mM	0.4187 mL	2.0936 mL	4.1873 mL	20.9363 mL
10 mM	0.2094 mL	1.0468 mL	2.0936 mL	10.4681 mL
20 mM	0.1047 mL	0.5234 mL	1.0468 mL	5.2341 mL
50 mM	0.0419 mL	0.2094 mL	0.4187 mL	2.0936 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc