Shopping Cart
Remove All
Your shopping cart is currently empty
OSIP-486823
🥰Excellent
Catalog No. T13807Cas No. 200803-37-8
Alias CP248
OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
OSIP-486823
🥰Excellent
Purity: 98.59%
Catalog No. T13807Alias CP248Cas No. 200803-37-8
OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $469 | - | In Stock | |
| 5 mg | $987 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Batch Information
Select Batch
Purity:98.59%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules. |
| Targets&IC50 | SW48 cells:0.1 μM |
| In vitro | In SW480 human colon cancer cells, OSIP-486823 inhibits growth and induces apoptosis with an IC50 of 0.1 μM. OSIP-486823, a member of a new class of drugs known as selective apoptotic antineoplastic drugs targeting cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE), causes depolymerization of microtubules in interphase cells, inhibits spindle formation in mitotic cells, and induces multinucleated cells. Furthermore, OSIP-486823 disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells [1]. |
| Synonyms | CP248 |
| Molecular Weight | 473.54 |
| Formula | C29H28FNO4 |
| Cas No. | 200803-37-8 |
| Smiles | COc1cc(\C=C2\C(C)=C(CC(=O)NCc3ccccc3)c3cc(F)ccc23)cc(OC)c1OC |
| Relative Density. | 1.206 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy OSIP-486823 | purchase OSIP-486823 | OSIP-486823 cost | order OSIP-486823 | OSIP-486823 chemical structure | OSIP-486823 in vitro | OSIP-486823 formula | OSIP-486823 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.