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CRK12-IN-2

Name: CRK12-IN-2
Brand: TargetMol
SKU: T63727
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T63727Cas No. 1990479-17-8

CRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.CRK12-IN-2 can be used for the prevention and treatment of trypanosomiasis in animals.

CRK12-IN-2

🥰Excellent

Purity: 99.70%

Catalog No. T63727Cas No. 1990479-17-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$290	In Stock	In Stock
10 mg	$415	In Stock	In Stock
25 mg	$648	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.70%

ee:100%

Resource Download

COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.CRK12-IN-2 can be used for the prevention and treatment of trypanosomiasis in animals.
In vivo	Administered subcutaneously at a dosage of 10 mg/kg once daily for 4 days, CRK12-IN-2 effectively cures mice infected with T. congolense and T. vivax[1].

Chemical Properties

Molecular Weight	529.67
Formula	C₂₃H₃₃F₂N₅O₃S₂
Cas No.	1990479-17-8
Smiles	C(=O)(C=1SC(N[C@@H]2CC[C@@H](NS(CC(C)C)(=O)=O)CC2)=NC1N)C3=C(F)C=C(CN(C)C)C=C3F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (103.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8880 mL	9.4398 mL	18.8797 mL	94.3984 mL
5 mM	0.3776 mL	1.8880 mL	3.7759 mL	18.8797 mL
10 mM	0.1888 mL	0.9440 mL	1.8880 mL	9.4398 mL
20 mM	0.0944 mL	0.4720 mL	0.9440 mL	4.7199 mL
50 mM	0.0378 mL	0.1888 mL	0.3776 mL	1.8880 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc