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STF-083010

Catalog No. T6681 CAS 307543-71-1

Synonyms: STF083010

STF-083010 is a selective inhibitor of the IRE1α endonuclease.

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STF-083010, CAS 307543-71-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 73.00
25 mg	In stock	$ 123.00
50 mg	In stock	$ 215.00
100 mg	In stock	$ 387.00
200 mg	In stock	$ 585.00
500 mg	In stock	$ 853.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 98.85%

Purity: 97.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	STF-083010 is a selective inhibitor of the IRE1α endonuclease.
In vitro	WaC3 cells respond to treatments with STF-083010 with gradually decreased growth. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 hours cultures. In MM.1R MM, MM.1S, and RPMI 8226 cell lines, STF-083010 displays cytostatic and cytotoxic activity in a dose and time-dependent manner. In Eμ-TCL1 CLL cells, STF-083010 displays about 70% growth inhibition after 3 days culture. In SU8686, Panc0403, and MiaPaCa2 cell lines, STF-083010 blocks IRE1α's endonuclease and inhibits XBP1 splicing activity without affecting its kinase activity.
In vivo	STF-083010 (i.p., 30 mg/kg) signi?cantly inhibits the growth of the tumor in human multiple myeloma (MM) xenografts model.
Kinase Assay	Autophosphorylation activity is measured by adding of 32P-γ ATP. Endonuclease activity is measured by the adding of radiolabeled HAC1 508-nt RNA substrate synthesized in vitro using α32P-UTP. Mix STF083010 with recombinant hIRE1 protein, radiolabeled HAC1 508 nt RNA, and appropriate buffers to incubate. Kinase activity is quantitated by polyacrylamide gel electrophoresis. RNAsecleavage products are quantitated by 32P-γATP or 32P-UTP autoradiography.
Cell Research	3×10E3 (Panc0403, Panc1005, BxPc3, and MiaPaCa2) cell lines are seeded in 96-well plates overnight, and STF-083010(~50 μM) treatment for 48 hours started the next day.
Animal Research	NOD/SCID/IL2Rγ null mice were injected intraperitoneally of STF-083010(30 mg/kg) dissolved in 16% chremophor.

Synonyms	STF083010
Molecular Weight	317.38
Formula	C15H11NO3S2
CAS No.	307543-71-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.7 mg/mL (100 mM)

References and Literature

1. Papandreou l, et al. Blood. 2011, 117(4), 1311-1314. 2. ChienW, et al. Oncotarget. 2014, 5(13), 4881-4894. 3. Kriss CL, et al. Blood. 2012, 120(5), 1027-1038.

Citations

1. Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Endoplasmic Reticulum Stress Compound Library Bioactive Compound Library Anti-Diabetic Compound Library NO PAINS Compound Library Kinase Inhibitor Library Cell Cycle Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library

Related Products

Related compounds with same targets

IXA4 MKC8866 GSK2850163 (S enantiomer) IRE1α kinase-IN-8 B I09 IRE1α kinase-IN-9 IXA6 APY29

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

STF-083010 307543-71-1 Cell Cycle/Checkpoint IRE1 STF 083010 Inositol requiring enzyme 1 Inhibitor inhibit STF083010 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.