Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 39.00 | |
100 mg | In stock | $ 55.00 | |
200 mg | In stock | $ 80.00 | |
500 mg | In stock | $ 133.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
In vitro | Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity. |
In vivo | Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes. |
Synonyms | LY170053 |
Molecular Weight | 312.43 |
Formula | C17H20N4S |
CAS No. | 132539-06-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 31.2 mg/mL (100 mM)
DMSO: 31.2 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Olanzapine 132539-06-1 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Adrenergic Receptor AChR Inhibitor Beta Receptor cell Apoptosis Muscarinic acetylcholine receptor mAChR damage Mitophagy inhibit antipsychotic Serotonin Receptor neuronal anticholinergic 5-hydroxytryptamine Receptor Autophagy LY-170053 Mitochondrial Autophagy LY170053 5-HT2 mitochondrial SH-SY5Y LY 170053 inhibitor