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Meropenem

Catalog No. T0224 CAS 96036-03-2

Synonyms: SM 7338

Meropenem (SM 7338) is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents. Meropenem is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury.

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Meropenem, CAS 96036-03-2

Pack Size	Availability	Price/USD
50 mg	In stock	$ 42.00
100 mg	In stock	$ 58.00
200 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.02%

Purity: 96.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Meropenem (SM 7338) is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents. Meropenem is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury.
In vitro	Meropenem significantly increases the urinary excretion of valproate-glucuronide in rabbits.
In vivo	Meropenem exhibits an antibacterial spectrum similar to that of imipenem, but demonstrates slightly lower activity against Staphylococcus aureus and Enterococcus. It possesses enhanced activity against Pseudomonas aeruginosa, all Enterobacteriaceae, and Haemophilus influenzae. Meropenem's antimicrobial efficacy against Gram-negative organisms is two to four times greater than that of imipenem, and it has a broader spectrum in comparison to all other tested agents. Furthermore, Meropenem exhibits an antagonistic effect when combined with several beta-lactam antibiotics against strain-producing type I cephalosporins. It binds most effectively to the penicillin-binding proteins 2 of Escherichia coli and Pseudomonas aeruginosa, and to the penicillin-binding protein 1 of Staphylococcus aureus.
Kinase Assay	Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.

Synonyms	SM 7338
Molecular Weight	383.46
Formula	C17H25N3O5S
CAS No.	96036-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 71 mg/mL (185.2 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 8 mg/mL (20.86 mM)

References and Literature

1. Edwards JR, et al. J Antimicrob Chemother, 1995, 36 Suppl A, 1-17. 2. Jones RN, et al. J Antimicrob Chemother, 1989, 24 Suppl A, 9-29. 3. Yang Y et al. J Antimicrob Chemother, 1995, 35(1), 75-84. 4. Drusano GL, et al. Scand J Infect Dis Suppl, 1995, 96, 11-16. 5. Yokogawa K, et al. Pharm Res, 2001, 18(9), 1320-1326. 6. Yang K, Li H Z, Zhu X, et al. Rapid Antibiotic Susceptibility Testing of Pathogenic Bacteria Using Heavy Water-Labeled Single-Cell Raman Spectroscopy in Clinical Samples[J]. Analytical chemistry. 2019 May 7;91(9):6296-6303.

Citations

1. Yang K, Li H Z, Zhu X, et al. Rapid Antibiotic Susceptibility Testing of Pathogenic Bacteria Using Heavy Water-Labeled Single-Cell Raman Spectroscopy in Clinical Samples. Analytical chemistry. 2019 May 7;91(9):6296-6303. 2. Sun J, Ren S, Yang Y, et al.Betaxolol as a Potent Inhibitor of NDM-1-Positive E. coli That Synergistically Enhances the Anti-Inflammatory Effect in Combination with Meropenem.International Journal of Molecular Sciences.2023, 24(17): 13399.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Drug-induced Liver Injury (DILI) Compound Library Beta-Lactam Compound Library Pediatric Drug Library Antibiotics Library Anti-Infection Compound Library Anti-Bacterial Compound Library ReFRAME Related Library

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Keywords

Meropenem 96036-03-2 Microbiology/Virology Others Antibiotic Antibacterial anaerobic parenteral neutropenia Gram-positive Inhibitor SM7338 SM 7338 DHP-1 carbapenem β-lactamases Bacterial Gram-negative SM-7338 inhibit inhibitor

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