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Icariin

Catalog No. T2855 CAS 489-32-7

Synonyms: Ieariline

Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.

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Icariin, CAS 489-32-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 47.00
200 mg	In stock	$ 67.00
500 mg	In stock	$ 107.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 98.49%

Purity: 98.04%

Purity: 97.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
Targets&IC50	PDE5:0.432 μM
Source	Natural Products > Berberidaceae > Epimedium

Synonyms	Ieariline
Molecular Weight	676.66
Formula	C33H40O15
CAS No.	489-32-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (88.67 mM)

References and Literature

1. Song YX, et al. Chin J Integr Med. 2015 Nov 20. 2. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 3. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 4. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2021, 19(1): 1-14.

Citations

1. Wang G, Li X, Li N, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biology. 2022: 102297. 2. Wang G, Li X, Li N, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biology. 2022, 52: 102297 3. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2021 Feb 11;19(1):13. doi: 10.1186/s12964-020-00647-1. 4. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2020 5. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 2020

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Miao medicine Compound Library Highly Selective Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Endoplasmic Reticulum Stress Compound Library Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Icariin 489-32-7 Autophagy DNA Damage/DNA Repair Metabolism PDE PPAR Ieariline inhibit Phosphodiesterase (PDE) Peroxisome proliferator-activated receptors Inhibitor inhibitor

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