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Gossypol

Catalog No. T6518   CAS 303-45-7
Synonyms: Pogosin, BL 193, NSC 56817

Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

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Gossypol Chemical Structure
Gossypol, CAS 303-45-7
Pack Size Availability Price/USD Quantity
10 mg In stock $ 35.00
25 mg In stock $ 57.00
50 mg In stock $ 83.00
100 mg In stock $ 122.00
500 mg In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.89%
Purity: 99.8%
Purity: 99.31%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
Targets&IC50 Bcl-2:0.2-0.3 mM (Ki), Bcl-xL:0.5-0.6 μM (Ki)
In vitro Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2].
Cell Research MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference)
Source
Synonyms Pogosin, BL 193, NSC 56817
Molecular Weight 518.55
Formula C30H30O8
CAS No. 303-45-7

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (96.42 mM)

TargetMolReferences and Literature

1. Ciereszko A, et al. Aquat Toxicol, 2000,49(3):181-187. 2. Yongqiang Zhao, et al. Blood. 2005, 106:4405. 3. Udoh P, et al. Contraception. 1992, 45(5):493-509. 4. Lin J, et al. Oncol Rep. 2013, 30(2):731-738. 5. Tang J, et al. Int J Clin Exp Med. 2015, 8(6):9079-85.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Polyphenolic Natural Product Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library PPI Inhibitor Library Target-Focused Phenotypic Screening Library

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Keywords

Gossypol 303-45-7 Apoptosis Metabolism Dehydrogenase BCL Inhibitor BL193 Pogosin NSC56817 BL 193 BL-193 NSC 56817 Bcl-2 Family inhibit NSC-56817 inhibitor

 

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