keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 35.00 | |
25 mg | In stock | $ 57.00 | |
50 mg | In stock | $ 83.00 | |
100 mg | In stock | $ 122.00 | |
500 mg | In stock | $ 297.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. |
Targets&IC50 | Bcl-2:0.2-0.3 mM (Ki), Bcl-xL:0.5-0.6 μM (Ki) |
In vitro | Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2]. |
Cell Research | MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference) |
Source |
Synonyms | Pogosin, BL 193, NSC 56817 |
Molecular Weight | 518.55 |
Formula | C30H30O8 |
CAS No. | 303-45-7 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (96.42 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Gossypol 303-45-7 Apoptosis Metabolism Dehydrogenase BCL Inhibitor BL193 Pogosin NSC56817 BL 193 BL-193 NSC 56817 Bcl-2 Family inhibit NSC-56817 inhibitor