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7-Dehydrocholesterol

Catalog No. T4923 CAS 434-16-2

Synonyms: Provitamin D3, 7-DHC

7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.

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7-Dehydrocholesterol, CAS 434-16-2

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 47.00
500 mg	In stock	$ 112.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.
In vitro	7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen.

Synonyms	Provitamin D3, 7-DHC
Molecular Weight	384.64
Formula	C27H44O
CAS No.	434-16-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (28.6 mM)

References and Literature

1. Lehmann B , Genehr T , Knuschke P , et al. UVB-Induced Conversion of 7-Dehydrocholesterol to 1α,25-Dihydroxyvitamin D3 in an In Vitro Human Skin Equivalent Model[J]. Journal of Investigative Dermatology, 2001, 117(5):1179. 2. Muzzin K B, Harper L F. Smith-Lemli-Opitz syndrome: a review, case report and dental implications[J]. Special Care in Dentistry, 2010, 23(1):22-27. 3. Johnson D W, ten Brink H J, Jakobs C. A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry[J]. Journal of Lipid Research, 2001, 42(10):1699-705. 4. Ho C , Fung C , Siu T , et al. Lathosterolosis: A Disorder Of Cholesterol Biosynthesis Resembling Smith-lemli-opitz Syndrome[J]. Jimd Rep, 2013, 12:129-134. 5. Sethi J K, Vidalpuig A J. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.[J]. Journal of Lipid Research, 2007, 48(6):1253-1262.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Human Endogenous Metabolite Library PBCRBS Traditional Chinese Medicine Compound Library Approved Drug Library Human Metabolite Library NO PAINS Compound Library Chinese Pharmacopoeia Natural Product Library FDA-Approved & Pharmacopeia Drug Library Mouse Metabolite Compound Library Natural Product Library for HTS

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Keywords

7-Dehydrocholesterol 434-16-2 Metabolism Endogenous Metabolite 7 Dehydrocholesterol Inhibitor Provitamin D3 7-DHC 7Dehydrocholesterol inhibit inhibitor

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