Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | 6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties. |
Targets&IC50 | Androgen receptor:3.3 µM |
In vivo | 6-Hydroxyflavanone (6-HF) (6-HF) (5, 30, and 60 mg/kg ) inhibited the COX-2 and 5-LOX enzymes significantly. It substantially reduced heat nociception in a hot plate analgesia meter, as well as carrageenan-induced paw edema in rodent models. The authors discovered that 6-HF exhibited anti-nociception properties in a streptozotocin-induced diabetic neuropathy (DIN) model. According to the findings of this study, 6-HF demonstrated the ability to diminish inflammation caused by diabetes, as well as to exert an anti-nociceptive.[3] |
Molecular Weight | 240.25 |
Formula | C15H12O3 |
CAS No. | 4250-77-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.4 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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6-Hydroxyflavanone 4250-77-5 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Neuroscience Others Lipoxygenase COX GABA Receptor 6Hydroxyflavanone 6 Hydroxyflavanone inhibitor inhibit