Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 276.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 588.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | 4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) |
In vitro | 4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade. |
In vivo | In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction.?Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation. |
Cell Research | Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours |
Animal Research | Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks |
Synonyms | 4-Iodo-6-phenylpyrimidine |
Molecular Weight | 282.08 |
Formula | C10H7IN2 |
CAS No. | 41270-96-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (106.35 mM)
You can also refer to dose conversion for different animals. More
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