Powder: -20°C for 3 years | In solvent: -80°C for 1 year
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 153.00 | |
5 mg | In stock | $ 221.00 | |
10 mg | In stock | $ 337.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 785.00 | |
100 mg | In stock | $ 1,120.00 |
Description | 360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). |
Targets&IC50 | Telomerase:300 nM |
In vitro | A549 lung carcinoma cell lines treatment with 5 μM of 360A led to an inhibition of cell proliferation within 11 days of treatmen. Treatment with the newly synthesized dimer (360A)2A led to a comparable antiproliferative effect[1] |
Cell Research | Supplemented with 10% fetal calf serum (FCS) and 1% penicillin/streptomycin. A549 cells were maintained in humidified incubators at 37 °C in an atmosphere containing 5% CO2 and ambient oxygen of 20%. Cells were grown in 25 cm^2 flasks (150,000 cells/flask) and treated with 5 μM of 360A or (360A)2A every 3 or 4 days (i.e., at each reseeding) until cultures were terminated. Control cells were either non-treated or treated with 0.1% DMSO. At each reseeding the remaining cells were pelleted and snap frozen for further DNA extraction.Statistical analysis was performed using GraphPad Prism 5. A Chi-square test was used to compare TDEs frequencies[1]. |
Molecular Weight | 449.5 |
Formula | C27H23N5O2 |
CAS No. | 794458-56-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
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360A 794458-56-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Telomerase DNA/RNA Synthesis inhibit Inhibitor G-quadruplex inhibitor