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3-O-Methylquercetin

Catalog No. TN1266 CAS 1486-70-0

3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low Km value. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

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3-O-Methylquercetin, CAS 1486-70-0

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1 mg	In stock	$ 89.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 297.00
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Purity: 99.8%

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Description	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low Km value. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.
Targets&IC50	PDE1-PDE5:1.6-86.9 μM
In vitro	Formulations composed of octyldodecanol, egg lecithin, water (NE) and cetyl trimethyl ammonium bromide (CNE) were obtained by spontaneous emulsification. This procedure yielded monodisperse nanoemulsions exhibiting a mean droplet size of approximately 200-300 nm. Nanoemulsions were further characterized in terms of zeta-potential, surface tension, and morphology by transmission electron microscopy. The amount of flavonoids incorporated into nanoemulsions reached nearly 100% (at 1 mg/mL). The permeation studies were carried out using ear pig skin mounted in Franz diffusion cells[1]
Source	Natural Products > Euphorbiaceae > Croton

Molecular Weight	316.26
Formula	C16H12O7
CAS No.	1486-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fasolo D, Bassani VL, Teixeira HF. Development of topical nanoemulsions containing quercetin and 3-O-methylquercetin. Pharmazie. 2009 Nov;64(11):726-30. 2. Wun-Chang Ko, et al. 3-O-methylquercetin More Selectively Inhibits Phosphodiesterase Subtype 3. Planta Med. 2003 Apr;69(4):310-5.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Cuproptosis Compound Library RO5 Drug-like Natural Product Library

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Keywords

3-O-Methylquercetin 1486-70-0 GPCR/G Protein Immunology/Inflammation Metabolism IL Receptor cAMP PDE 3OMethylquercetin Phosphodiesterase (PDE) inhibit 3 O Methylquercetin Inhibitor inhibitor

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