store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for collagen-induced platelet aggregation with IC50 values of 12.3 and 61.5µM, respectively. 3'-Methoxydaidzein acts as an analgesic by inhibiting voltage-gated sodium channels. 3'-Methoxydaidzein showed antioxidant activity and antiplatelet aggregation activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 369.00 | |
10 mg | In stock | $ 591.00 | |
25 mg | In stock | $ 935.00 | |
50 mg | In stock | $ 1,260.00 |
Description | 3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for collagen-induced platelet aggregation with IC50 values of 12.3 and 61.5µM, respectively. 3'-Methoxydaidzein acts as an analgesic by inhibiting voltage-gated sodium channels. 3'-Methoxydaidzein showed antioxidant activity and antiplatelet aggregation activity. |
Targets&IC50 | NaV1.7:181 nM, NaV1.8:397 nM, NaV1.3:397 nM |
In vitro | 3'-Methoxydaidzein, their antioxidant activities were investigated and compared with butylated hydroxyluene (BHT) and α±-tocopherol. The results showed that 3'-Methoxydaidzein had antioxidant activity. When the individual components (0.02%) were mixed with 0.02% BHT, or 0.02% α±-tocopherol, their protection factor was increased, but there was no synergistic effect. When the individual component had 4 ppm added Fe3+, 3'-Methoxydaidzein had antioxidant activity. Their antioxidant activities were tested by an oxidative stability instrument (OSI) at 100°C.[1] |
In vivo | 3'-Methoxydaidzein shows strong analgesic potential without inducing addiction through inhibiting subtypes NaV1.7, NaV1.8 and NaV1.3 with the IC50 of 181 ± 14, 397 ± 26, and 505 ± 46 nmol·L-1, respectively, providing a promising compound or parent structure for the treatment of pain pathologies. This study reveals a pain-alleviating mechanism of dietary isoflavones and may provide a convenient avenue to alleviate pain.[2] |
Molecular Weight | 284.26 |
Formula | C16H12O5 |
CAS No. | 21913-98-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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3'-Methoxydaidzein 21913-98-4 Membrane transporter/Ion channel Sodium Channel 3'Methoxydaidzein 3' Methoxydaidzein inhibitor inhibit