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2-HBA

Catalog No. T7374   CAS 131359-24-5

2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

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2-HBA Chemical Structure
2-HBA, CAS 131359-24-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 62.00
10 mg In stock $ 91.00
25 mg In stock $ 193.00
50 mg In stock $ 353.00
100 mg In stock $ 596.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 95.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
In vitro 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM[1]
Molecular Weight 266.29
Formula C17H14O3
CAS No. 131359-24-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (375.53 mM)

TargetMolReferences and Literature

1. Dinkova-Kostova A T , Cory A H , Bozak R E , et al. Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway[J]. Cancer Letters, 2007, 245(1-2):0-349. 2. Dinkova-Kostova A T , Holtzclaw W D , Cole R N , et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants[J]. Proceedings of the National Academy of Sciences, 2002, 99(18):11908-11913.

Related compound libraries

This product is contained In the following compound libraries:
Apoptosis Compound Library Anti-Metabolism Disease Compound Library Anti-Cancer Compound Library Bioactive Compound Library NO PAINS Compound Library Pyroptosis Compound Library Metabolism Compound Library Anti-Fibrosis Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max

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Keywords

2-HBA 131359-24-5 Apoptosis Metabolism Proteases/Proteasome NADPH Caspase inhibit Inhibitor 2HBA 2 HBA inhibitor

 

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